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Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research

Posted by Karen Chelcun Schreiber On July - 20 - 2010

An article published recently in the Journal of Medical Genetics outlines new recommendations for management of patients and families with Hereditary Diffuse Gastric Cancer, based on a workshop of the International Gastric Cancer Linkage Consortium (IGCLC) held in late 2008.  The workshop, convened in Cambridge, UK, included expert geneticists, gastroenterologists, oncologists, surgeons, and pathologists from nine countries, and discussion topics included genetic counselling and testing, surveillance endoscopy, prophylactic gastrectomy, and review of pathology specimens.

Some of the outcomes of the IGCLC workshop include: Read the rest of this entry »

Education, Front, Gastrectomy, Genetics, HDGC, Hereditary Diffuse Gastric Cancer, Lobular Breast Cancer, Research

Pregnancy after prophylactic total gastrectomy

Posted by Karen Chelcun Schreiber On February - 1 - 2010

The possibility of having a healthy pregnancy and maintaining one’s own health is an issue that comes up again and again for young women who are affected by Hereditary Diffuse Gastric Cancer (HDGC) and are contemplating prophylactic total gastrectomy.  Pardeep Kaurah provides the following report titled “Pregnancy after prophylactic total gastrectomy,”  which was just published in January, 2010.

Pregnancy after prophylactic total gastrectomy

Front, Pregnancy, Research

HDGC Research: In pursuit of stomach cancer prevention

Posted by Karen Chelcun Schreiber On November - 11 - 2009

A  prestigious James Cook Fellowship has been awarded to researcher Parry Guilford, University of Otazo, New Zealand, to pursue innovative research aimed at reversing or preventing the very early stages of stomach cancer.

Read Parry Guilford’s personal post detailing his exciting research plan for HDGC / CDH1 gene research.  His two year fellowship will begin in March, 2010.

 

The University of Otago announces Parry Guilford’s exciting award for  stomach cancer research.

More information about The Royal Society of New Zealand James Cook Research Fellowships.

Front, Genetics, HDGC, Hereditary Diffuse Gastric Cancer, Research

New Zealand Government Research Fellowship: Focus on HDGC and diffuse gastric cancer

Posted by Parry Guilford On November - 11 - 2009

Parry Guilford; Cancer Genetics Laboratory, University of Otago

The James Cook Fellowship provides funding for two years of concentrated research, free of teaching and administrative commitments.  My planned research is built broadly around establishing methods to assess individual risk of developing gastric cancer.  As we all know, CDH1 mutation carriers have a lifetime risk of around 70-80% of developing diffuse gastric cancer, but we have little understanding of an individual’s actual risk at any particular point in time. A better understanding of this would help individual carriers decide what the best time for surgical intervention is.  Read the rest of this entry »

Front, HDGC, Hereditary Diffuse Gastric Cancer, Research

Facts about Stomach Cancer and Stomach Cancer Research Funding

Posted by Johanna Chelcun On June - 30 - 2009

By Johanna Chelcun, PA-C

 

Did you know…

 

…that Hereditary Diffuse Gastric Cancer (HDGC) is an inherited cancer syndrome that leads to an increased risk for diffuse gastric cancer (67-83% risk by age 80) and lobular breast cancer (20-40% risk for women by age 80.)

 

…that the American Cancer Society estimated that one million people worldwide would be diagnosed with stomach cancer in the year 2007, and that 800,000 would die from the disease? Read the rest of this entry »

Education, Front, Fundraising, Get Involved, HDGC, Hereditary Diffuse Gastric Cancer, Research

Hereditary Diffuse Gastric Cancer: British Columbia Cancer Agency Research Update June 2009

Posted by Karen Chelcun Schreiber On June - 22 - 2009

Current Research Projects of the Hereditary Diffuse Gastric Cancer Research Team at the British Columbia Cancer Agency.

David Huntsman, Pardeep Kaurah
 

Over the last 10 years, we have learnt a lot about hereditary diffuse gastric cancer (HDGC). However, there are still many critical knowledge deficits which need to be addressed to improve the cancer control of families with known CDH1 mutations and to inform the care of families with strong histories of gastric cancer of whom known mutations have been identified.

 

Our research team is both collaborating with other members of the International Gastric Cancer Linkage Consortium (IGCLC) to develop a more accurate understanding of the cancer risks associated with carrying CDH1 mutations, and is performing research locally that should help our global research community move forward.

 

Studies we are actively engaged in include: Read the rest of this entry »

Front, HDGC, Hereditary Diffuse Gastric Cancer, Research

TV New Zealand Close Up: The Kiwis who inspired a Grey’s plot

Posted by Karen Chelcun Schreiber On June - 14 - 2009

View an uplifting and interesting Close Up news broadcast about Hereditary Diffuse Gastric Cancer (HDGC) on TV New Zealand featuring Parry Guilford, the scientist who first identified HDGC and the CDH1 gene mutation that causes HDGC.  His discovery, only eleven years new, has been saving so many lives, including in the Chelcun family and many other families worldwide.  The Close Up includes interviews with the original families in whom HDGC was first identified.  We must find ways to fund the promising research that will ultimately lead to the prevention of this particular cancer as well as other related cancers.

Families, Fundraising, Genetics, HDGC, Hereditary Diffuse Gastric Cancer, News, Research

Hereditary Diffuse Gastric Cancer (HDGC): A Resource for You

Posted by Karen Chelcun Schreiber On June - 13 - 2009

HDGC...Now What?

Be sure to visit HDGC…Now What?

 

You, or someone close to you has been diagnosed with HDGC.  Now what?  The search is on, for information, for support, for encouragement.

  
We are committed to developing this network, a valuable source of credible and useful information.  Join our community of support for all of those touched by HDGC or other types of stomach cancer.  Your participation can be as little or as much as you desire.  You decide. Read the rest of this entry »

Education, Families, Fundraising, Gastrectomy, General, Genetics, Get Involved, HDGC, Hereditary Diffuse Gastric Cancer, Lobular Breast Cancer, Mind, Body, Spirit, News, Nutrition, Pregnancy, Research

New Zealand Listener, Interview with Parry Guilford

Posted by Karen Chelcun Schreiber On June - 10 - 2009

When the hospital drama Grey’s Anatomy screens on June 14 (in New Zealand), there will be a ripple of pride through the corridors of Otago University’s Cancer Genetics Laboratory.  That’s because one of the main storylines in the episode - a family grappling with the terrible consequences of inherited stomach cancer - has its origins in a 1998 discovery by researchers at the laboratory, let my Oamaru-raised geneticist Parry Guilford.

Read the Interview with Parry Guilford, by Rebecca Macfie

Front, Genetics, HDGC, Hereditary Diffuse Gastric Cancer, Research

Raquel Seruca Curriculum Vitae 2009

Posted by Karen Chelcun Schreiber On May - 28 - 2009
Raquel Seruca Curriculum Vitae 2009

Read the rest of this entry »

Research

Cancer Genetics Group in Portugal: Focus on the genetics of gastric, breast, and colorectal carcinoma

Posted by Karen Chelcun Schreiber On May - 22 - 2009

Group name/Designation:

Cancer Genetics

 

Group Leader:

Raquel Seruca

Principal Investigators related to gastric cancer research:
Carla Oliveira ( HDGC molecular genetics),
Fátima Carneiro ( Molecular Pathology),
Gianpaolo Suriano and Jose Carlos Machado ( Gastric cancer related signalling pathways)
Céu Figueiredo (Helicobacter pylori related research)

 

Principal Investigators related to breast cancer research:
Joana Paredes (Signalling pathways related to breast cancer invasion), 
Fernando Schmitt ( Molecular pathology),

Location of the Group (Host- Institution):

 IPATIMUP, Porto, Portugal

  

General Objectives of the Group

The research of our group focuses on the genetics of three common types of epithelial cancer: gastric, breast, and colorectal carcinoma. We focus at identifying 1) germline genetic alterations (high and low penetrance genes) associated with increased risk of these tumours; 2) pathological features and somatic molecular markers occurring in the setting of hereditary and sporadic carcinomas; 3) signalling pathways mediated by genetic and gene-environmental factors in tumour development in order to find molecular targets for therapeutic intervention. Read the rest of this entry »

Front, HDGC, Hereditary Diffuse Gastric Cancer, Lobular Breast Cancer, Research

Gregory Y. Lauwers Curriculum Vitae 2009

Posted by Karen Chelcun Schreiber On May - 22 - 2009

GREGORY Y. LAUWERS, M.D.

(Curriculum Vitae prepared on May 11, 2009) Read the rest of this entry »

Research
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    • Lorraine Ennis wrote on the wire of the group Lobular Breast Cancer   1 day, 20 hours ago

      Hi Nina……..great to see you here when we live only minutes apart and can’t seem to get together!!

      Just to let everyone know, when Nina said “Thanks Marge” she is referring to my sister who has spend a great deal of time, energy and efforts in educating our family about this gene…….if it wasn’t for her, [...]

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    • J Wielgoszinski updated the “Cancer Profile” information on their profile   1 week, 1 day ago

    • J Wielgoszinski updated the “Bio” information on their profile   1 week, 1 day ago

    • Karen Chelcun Schreiber wrote a new blog post: Scientific Advisory Board   1 week, 1 day ago

      Scientific Advisory Board members are highly accomplished professionals with medical and/or research background, who provide expert and comprehensive perspectives as well as guidance to No Stomach For Cancer, Inc. with regard to technical, medical, and research related topics. The Board provides knowledge and support that are critical in furthering our Mission.

       

      Daniel C. Chung, MD
      Clinical Chief, [...]

    • Nina healey wrote on the wire of the group Lobular Breast Cancer   1 week, 6 days ago

      I am new to this group. I am actually a cousin of Lorraine Ennis. In March 2007, I was diagnosed with Invasive Lobular Carcinoma in my right breast. I had a mastectomy in March, during which the dr checked the lymph nodes by removing the main node and checked it while I [...]

    • Nina healey joined the group Lobular Breast Cancer   1 week, 6 days ago