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Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research

Posted by Karen Chelcun Schreiber On July - 20 - 2010

An article published recently in the Journal of Medical Genetics outlines new recommendations for management of patients and families with Hereditary Diffuse Gastric Cancer, based on a workshop of the International Gastric Cancer Linkage Consortium (IGCLC) held in late 2008.  The workshop, convened in Cambridge, UK, included expert geneticists, gastroenterologists, oncologists, surgeons, and pathologists from nine countries, and discussion topics included genetic counselling and testing, surveillance endoscopy, prophylactic gastrectomy, and review of pathology specimens.

Some of the outcomes of the IGCLC workshop include: Read the rest of this entry »

Education, Front, Gastrectomy, Genetics, HDGC, Hereditary Diffuse Gastric Cancer, Lobular Breast Cancer, Research

Pregnancy after prophylactic total gastrectomy

Posted by Karen Chelcun Schreiber On February - 1 - 2010

The possibility of having a healthy pregnancy and maintaining one’s own health is an issue that comes up again and again for young women who are affected by Hereditary Diffuse Gastric Cancer (HDGC) and are contemplating prophylactic total gastrectomy.  Pardeep Kaurah provides the following report titled “Pregnancy after prophylactic total gastrectomy,”  which was just published in January, 2010.

Pregnancy after prophylactic total gastrectomy

Front, Pregnancy, Research

Increased Risk of Colon Cancer in HDGC Patients

Posted by Karen Chelcun Schreiber On January - 30 - 2010

The following is an excerpt from the as yet unpublished Cambridge meeting. The paper has just been accepted by the Journal of Medical Genetics and will be published early in the new year.

“There is also emerging evidence for an increased risk of colon cancer in HDGC families, and these colon cancers can display signet ring cell features (personal communications David Huntsman and Paul Pharoah). In CDH1 families in which colon cancer is reported information should be collected concerning the age at diagnosis, whether the affected member(s) are first or second degree relatives and whether the pathology was mucinous or showed signet ring cells. Depending on these factors enhanced screening should be considered with colonoscopy beginning at age 40 or 10 years younger than the youngest diagnosis of colon cancer, whichever is younger, and repeated at intervals of 3-5 years. It is imperative that data on colonoscopic screening in these individuals is collated so that these guidelines can be evidenced based in the future”.

Fitzgerald et al (2010) J.Med. Genet. in press.

Know your family history. Be proactive. Talk to your doctor about the health screenings that are appropriate for you.

Front

Hereditary Diffuse Gastric Cancer: British Columbia Cancer Agency Research Update June 2009

Posted by Karen Chelcun Schreiber On June - 22 - 2009

Current Research Projects of the Hereditary Diffuse Gastric Cancer Research Team at the British Columbia Cancer Agency.

David Huntsman, Pardeep Kaurah
 

Over the last 10 years, we have learnt a lot about hereditary diffuse gastric cancer (HDGC). However, there are still many critical knowledge deficits which need to be addressed to improve the cancer control of families with known CDH1 mutations and to inform the care of families with strong histories of gastric cancer of whom known mutations have been identified.

 

Our research team is both collaborating with other members of the International Gastric Cancer Linkage Consortium (IGCLC) to develop a more accurate understanding of the cancer risks associated with carrying CDH1 mutations, and is performing research locally that should help our global research community move forward.

 

Studies we are actively engaged in include: Read the rest of this entry »

Front, HDGC, Hereditary Diffuse Gastric Cancer, Research

Erin’s Gift Family Forum Notice

Posted by Karen Chelcun Schreiber On March - 12 - 2009

Notice from Erin’s Gift regarding a Family Forum in Canada:

Add your name to the list of parties interested in attending a HDGC Family Forum. Plans are tentatively in the works for a forum in Vancouver, British Columbia, Canada for families affected by HDGC to be held within the next 3-5 years. The forum will include guest speakers such as Dr. David Huntsman. Please add your name to the contact list if you wish to receive further information as it develops.
March 2009

Families, Get Involved, Notices
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      Scientific Advisory Board members are highly accomplished professionals with medical and/or research background, who provide expert and comprehensive perspectives as well as guidance to No Stomach For Cancer, Inc. with regard to technical, medical, and research related topics. The Board provides knowledge and support that are critical in furthering our Mission.

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    • Nina healey wrote on the wire of the group Lobular Breast Cancer   1 week, 1 day ago

      I am new to this group. I am actually a cousin of Lorraine Ennis. In March 2007, I was diagnosed with Invasive Lobular Carcinoma in my right breast. I had a mastectomy in March, during which the dr checked the lymph nodes by removing the main node and checked it while I [...]

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    • Gretchen Borzi wrote on the wire of the group Lobular Breast Cancer   3 weeks, 2 days ago

      Lorraine and Cathy, you’re stories are inspiring. I wish you both the best of luck with your surgeries and recovery. Right now, it’s hard for me to imagine being in your shoes, but I will most likely be there at some point. Thanks for sharing.