Brief Resumé: Parry Guilford
Present Positions
Principal Investigator
Cancer Genetics Laboratory
University of Otago, Dunedin, New Zealand
Chief Scientific Officer
Pacific Edge Biotechnology Ltd
Dunedin
Qualifications
BSc (Otago), 1981; MSc (Otago) 1983; PhD (Cambridge), 1989
Research Activities
• Gene expression profiling
• Human genetics: inherited susceptibility to genetic disorders
• Cancer diagnostics
• Cancer biology
Refereed Publications:
Book Chapters
• Gastric Cancer: recent advances. Chapter: hereditary diffuse gastric cancer. Guilford, P, Humar, B and Blair V. 2008. Minerva Med, Turin, Italy.
• WHO classification of Tumours: Tumours of the digestive system; chapter: gastric carcinoma; P. Guilford; eds Stanley Hamilton and Lauri Aaltonen; IARC press Lyon 2000.
• Dunbier, A.K. and Guilford, P.J. Gastric Cancer: inherited predisposition. The encyclopedia of cancer. 2002.
Recent Reviews
• Humar, B and Guilford P. (2009). Hereditary Diffuse Gastric Cancer: a Manifestation of Lost Cell Polarity. Cancer Science (in press).
• Humar, B. and , P. Hereditary Diffuse Gastric Cancer and Lost Cell Polarity: A Short Path to Cancer (2008). Future Oncology, 4, 229-239.
• Guilford, P, Blair, V, More, H and Humar, B. (2007). A short guide to hereditary diffuse gastric cancer. Hereditary Cancer in Clinical Practice, 5(4), 183-194.
HDGC journal articles
1. Zou, D., Yoon, H-S., Perez, D., Weeks, R., Guilford, P. and Humar, B. Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. (2009) J. Path (accepted).
2. Humar, B; Blair, V; Charlton, A; More, H; Martin, I, Guilford, P. E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man. (2009). Cancer Res. 69, 2050-6.
3. Nasri S, More H, Graziano F, Ruzzo A, Wilson E, Dunbier A, McKinney C, Merriman T, Guilford P, Magnani M, Humar B. A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population. (2008). BMC Cancer 8, 138.
4. Humar, B., Fukuzawa, R., Blair, V., Dunbier, A., More, H., Charlton, A., Yang, H-K., Kim, W-H, Reeve, A.E., Martin, I. and Guilford, P. (2007). Destabilized adhesion in the gastric proliferative zone and c-src kinase activation mark the development of early diffuse gastric cancer. Cancer Res, 67, 2480-2489.
5. More, H., Humar, B., Weber, W., Ward, R., Christian, A., Lintott, C., Graziano, F., Ruzzo, A-M., Acosta, E., Boman, B., Harlan, M., Ferreira, P., Seruca, R., Suriano, G., and Guilford, P. (2007). Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene. Human Mutation 28, 203.
6. Ramos-De La Medina A, Medina-Franco H, More H, Humar B, Gamboa A, Ortiz LJ, Abarca L, Guilford P. Single nucleotide polymorphisms (SNPs) at CDH1 promoter region in familial gastric cancer. (2006) Revista Española De Enfermedades Digestivas: 98 (1) 36-41
7. Blair, V., Martin, I., Shaw, D., Winship, I., Kerr, D., Arnold, J., Harawira, P., McLeod, M., Parry, S., Charlton, A., Findlay, M., Cox, B., Humar, B., More, H, Guilford. P. Hereditary Diffuse Gastric Cancer: diagnosis and management. (2006) Clinical Gastroenterology and Hepatology, 4(3):262-275.
8. Shaw, D., Blair, V., Framp, A., Harawira, P., McLeod, M., Guilford, P., Parry, S., Charlton, A., Martin, I. (2005). Chromoendoscopic Surveillance in Hereditary Diffuse Gastric Cancer: an Alternative to Prophylactic Gastrectomy? Gut, 54, 461-468.
9. Charlton, A., Blair, V., Shaw, D., Parry, S., Guilford, P and Martin I.G. (2004). Hereditary diffuse gastric cancer: predominance of multiple foci of signet ring cell carcinoma in distal stomach and transitional zone. Gut, 53, 814-820.
10. Graziano, F., Arduini, F., Ruzzo, A., Bearzi, I., Humar, B., Silva, R., Muretto, P., Guilford, P., Testa, E., Mari, D., Magnani, M., Scartozzi, M., Berardi, R., Catalano, V. and Cascinu, S. Prognostic analysis of E-cadherin gene (CDH1) promoter hypermethylation in patients with surgically-resected, node-positive, diffuse gastric cancer. Clinical Cancer Research, 10, 2784-2789.
11. Da Silva Tatley, F., Aldwell, F.E., Dunbier, A.K., and Guilford, P.J. A putative heterozygote advantage associated with germline E-cadherin mutations. Infection and Immunity, 71, 1580-1583 (2003).
12. Humar, B., Graziano, F., Cascinu, S., Catalano, V., Ruzzo, A., Magnani, M., Toro, T., Burchill, T., Futschik, M., Merriman, T. and Guilford, P. Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer. Oncogene, 21,8192-5 (2002).
13. Humar, B., Toro, T., Graziano, F., Müller, H., Dobbie, Z., Kwang-Yang, H., Eng, C.., Hampel, H., Gilbert, D., Winship, I., Parry, S., Ward, R., Findlay, M., Christian, A., Tucker, M., Tucker, K., Merriman, T. and Guilford, P. Novel germline CDH1 mutations in hereditary diffuse gastric cancer families. Human Mutation, 19, 518-525 (2001).
14. Pharoah, P.D.P., Guilford, P., Caldas, C. and the International Gastric Cancer Linkage Consortium3 Incidence of gastric cancer and breast cancer in E-cadherin mutation carriers from hereditary diffuse gastric cancer families. Gastroenterology 121, 1348-1353 (2001).
15. Chun, Y-S.; Lindor, N.M., Smyrk, T.C., Bret T. Petersen, B. T. , Burgart, L.J., Guilford, P.J. and Donohue, J.H. Germline E-cadherin Gene Mutations: Is Prophylactic Total Gastrectomy Indicated? Cancer. 92, 181-187 (2001).
16. Grady, W.M., Willis, J., Guilford, P.J., Dunbier, A.K., Toro, T.T., Lynch, H., Wiesner, G., Ferguson, K., Eng, C., Park, J-G., Kim, S-J. & Markowitz, S. (2000). Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nature Genetics, 26, 16-17.
17. Park, J-G., Yang, H-K., Kim, W-H., Caldas, C., Yokota, J. and Guilford, P.J. (2000). Report on the First Meeting of the International Collaborative Group on Hereditary Gastric Cancer (ICG-HGC). J Natl Inst. Cancer. 92, 1781-1782.
18. Guilford, P.J., Hopkins, J.B.W., Grady, W.M., Markowitz, S.D., Willis, J., Lynch, H., Rajput, A, Wiesner, G.L., Lindor, N.M., Burgart, L.J., Toro, T.T., Lee, D., Limacher, J-M., Shaw, D.W., Findlay, M.P.N. and Reeve, A.E. E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. Human Mutation, 14, 249-255 (1999).
19. Shinmura, K., Kohno, T., Takahashi, M., Sasaki, A., Ochiai, A., Hunter, A., Guilford, P.J., Reeve, A.E., Sugimura, H., Yamaguchi, N. and Yokota. Familial gastric cancer: clinicopathological characteristics, RER phenotype, and germline p53 and E-cadherin mutations. Carcinogenesis, 20, 1127-1131 (1999).
20. Gardner, R.J.M., Gaff, C.L., Macrae, F.A., St John, J.B., Hopkins, J.B.W., Guilford, P.J. and Reeve, A.E. E-cadherin unlikely to be a common ‘low penetrance’ gene for colorectal cancer. Am. J. Med. Genet. 84, 169-171 (1999).
21. Guilford, P., Hopkins, J., Harraway, J., McLeod, M., McLeod, N., Harawira, P., Taite, H., Scoular, R., Miller, A. and Reeve, A.E. E-cadherin mutations in familial gastric cancer. Nature, 392, 402-405 (1998).
