Please note the following corrections to the HDGC Presentation that appears on the Education page:
The text of Slide 6 should read:
“The CDH1 gene, located on chromosome 16q22.1, normally encodes for a transmembrane glycoprotein called E-cadherin.
The text of Slide 10 should read:
So what can we tell our patients about the results of this genetic testing? If a negative result comes back, this implies that the patient inherited the normal CDH1 gene from the affected parent, and he or she has the same risk of developing gastric cancer as the general population. In this case, no screening or further action is necessary.
On the other hand, a positive test result means that the patient inherited the mutated CDH1 gene from their affected parent, and he or she is at an increased risk for developing diffuse-type gastric cancer. Additionally, female carriers are at an increased risk for developing lobular breast cancer, which will be discussed on the next slide. Cases of colorectal and prostate cancer have also been described in HDGC families, but they are so rare that it is thought that HDGC patients are at the normal population risk for development of these cancers.”
